NANOPARTICLE-MEDIATED TUMOR CELL EXPRESSION OF MIL-12 VIA SYSTEMIC GENE DELIVERY TREATS SYNGENEIC MODELS OF MURINE LUNG CANCERS

Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers

Abstract Treatment of cancers in the lung remains a critical challenge in the clinic for which Fly Veil gene therapy could offer valuable options.We describe an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediate tumor-specific expression of a therapeutic gene, under the control of the cancer-selective

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An efficient method to identify virus-specific TCRs for TCR-T cell immunotherapy against virus-associated malignancies

Abstract Adoptive transfer of T cells genetically engineered with a T cell receptor (TCR) is a promising cancer treatment modality that requires the identification of TCRs with good characteristics.Most T cell cloning methods involve a stringent singularization process, which Hayward C250 necessitates either tedious hands-on operations or high cost

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